Sparta have won all five of their Europa home fixtures this season, including the preliminary rounds, whereas Napoli have just one victory in their last six continental trips.
Dries Mertens is still out after being knocked unconscious a week ago for Belgi澳门外围投注线上足球投注a>um, while Lorenzo Insigne, Michu and Juan Camilo Zuniga are also on the treatment table.
Jonathan de Guzman was expected to start, but Gonzalo Higuain, Marek Hamsik and Jose Callejon all play with Jorginho in a more advanced trequartista role.
Napoli: Rafael; Mesto, Albiol, Koulibaly, Britos; Gargano, David Lopez; Callejon, Jorginho, Hamsik; Higuain
Napoli bench: Andujar, Henrique, Maggio, Ghoulam, De Guzman, Inler, Zapata
The Partenopei fought back from an early goal to win this fixture 3-1 at the San Paolo in September.
It kicks off at 18.00 GMT and finds both teams paired on nine points, followed by Young Boys on six.
Sparta bench: Vorel, Pamic, Svejdik, Kovac, Vacek, Pnkryl, Schick
The only real changes are in the full-back positions, where Giandomenico Mesto and Miguel Angel皇冠外围投注 Britos step in.
Sparta Prague confirm their usual line-up, including top scorer Lafata in attack.
Only two Italian clubs have ever beaten Sparta in Prague – Milan in 1973 and Lazio in 2000 – along with five draws and three defeats.
Napoli go into a head-to-head battle with joint Europa League group leaders Sparta Prague, starting almost an ideal XI.
Sparta Prague: Stech; Kaderabek, Brabec, Holek, Nhamoinesu; Husbauer, Mareček, Matejovsky; Dočkal, Lafata, Krejci