It kicks off at the Stadio San Paolo at 14.00 GMT, .
Napoli are forced into radical changes in this afternoon’s clash with Zdenek Zeman’s all-attack Cagliari.
Jonatha六合投注网站n de Guzman starts in the supporting trio behind Gonzalo Higuain with Walter Gargano, Paulo Henrique and Faouzi Ghoulam stepping in.
Lorenzo Insigne is out for five months with a knee ligament injury, while Dries Mertens was knocked unconscious during Belgium’s draw with Wales.
Zeman is familiar with the San Paolo, as he was Coach of Napoli for just six games in 2000 before getting the sack.
Michu and Juan Zuniga are also injured with Jorginho sitting out a ban, so Rafa Benitez had to completely revamp his line-up.
Napoli: Rafael; Maggio, Henrique, Koulibaly, Ghoulam; Gargano, Inler; Callejon, Hamsik, De Guzman; Higuain
Cagliari also have issues to deal with, as Daniele Conti is suspended with top scorer Marco Sau sidelined.
Cagliari: Cragno; Balzano, Ceppitelli, Rossettini, Pisano; Dessena, Crisetig, Ekdal; Ibarbo, Fa网络外围投注rias, Cossu
Cagliari have lost their last four trips to Naples, conced真人外围投注ing a grand total of 14 goals.
The Partenopei were in sparkling form going into the break for international duty and climbed to third place, but things have taken a turn for the worse during that two-week hiatus.
Others on the treatment table are Danilo Avelar and Simone Colombi, but Colombia international Victor Ibarbo returns from his ban.